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Alertec (Provigil)

We assessed prescription patterns for four top-selling orphan drugs: lidocaine patch (Lidoderm) approved for post-herpetic neuralgia, modafinil (Alertec) approved for narcolepsy, cinacalcet (Sensipar) approved for hypercalcemia of parathyroid carcinoma, and imatinib (Gleevec) approved for chronic myelogenous leukemia and gastrointestinal stromal tumor.

Other names for this medication:
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How Alertec works to help increase wakefulness and decrease sleepiness isn’t clear. The drug works in the brain to increase amounts of certain chemical messengers such as dopamine. It also seems to affect the messenger glutamate in certain areas of the brain.

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Alertec begins to work within 30 to 60 minutes of when you take it. If you take it with food, the drug might take slightly longer to start working.

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Characterization of antigenically and genetically similar influenza C viruses isolated in Japan during the 1999-2000 season. Between April 2002 and September 2012, 15 patients with large penile fistulas who were managed with TIPU were included in the study. Oxytocin released within the supraoptic nucleus of the rat brain by positive feedback action is involved in parturition-related events. A prospective study with a larger sample should be conducted to prove this particular finding.

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After the tumor volume is reconstructed from computed tomographic and magnetic resonance imaging data, a computer-monitored, stereotactically directed carbon dioxide laser is used to vaporize the intracranial tumor. Further studies with larger samples are necessary to confirm this observation. We discuss the problems of diagnosis and treatment of this syndrome in the light of a case report concerning a 43-year-old woman suffering from Churg-Strauss syndrome. Muscle and fat MR phantoms of known volumes were measured by the program. Cryptosporidium parvum was recognized as the cause of diarrhea in AIDS patients and also in immunocompetent humans where it only leads to a diarrheal episode lasting a few days.

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The study prospectively evaluated 160 patients with prostate cancer scheduled to undergo pelvic lymph node dissection (PLND) before or during definitive treatment. OVA, lysosome-associated membrane proteins (LAMP-1), and MHC class II antigens were localized in jejunal biopsy specimens of BALB/c and SCID mice at 0, 5, 10, 20, 40, 60, and 120 minutes after a single feed with OVA by fluorescence and electron microscopy. Infravesical obstructive uropathy secondary to extreme vulval atrophy Neuroactive peptides of the RFamide family can excite somatic muscle, for example, AF-1 (KNEFIRFamide), AF-2 (KHEYLRFamide), AF-3 (AVPGVLRFamide) and AF-4 (GDVPGVLRFamide) or inhibit and relax this muscle, for example, PF-1 (SDPNFLRFamide), PF-2 (SADPNFLRFamide) and PF-4 (KPNlRFamide). For children in both groups the following data were recorded: uncorrected visual acuity for distance and near, cycloplegic refraction, ocular motility, and binocular function.

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All neutral amino-acids are transported through the abluminal membrane by the L, A and ASC systems. BALB/c and C57BL/10 mice were immunized with this preparation and all developed an antibody response. To describe CT findings of non-tuberculous mycobacteria (NTM) pulmonary infection in non-AIDS immunocompromised patients (ICPs) and to compare these findings with those in immunocompetent patients.

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Clinicians are facing an unprecedented threat from antibiotic resistance, resulting in an increased reliance on the addition of an AGA to provide adequate empirical cover in cases of severe sepsis. The article supplies options for a business plan to present to administration to promote the team concept both in the hospital and in alternate site settings. There was no difference in detection thresholds between the AV(UM) condition and the A condition.

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Enzymes inhibition and antidiabetic effect of isolated constituents from Dillenia indica. Prognostic discrimination using a 70-gene signature among patients with estrogen receptor-positive breast cancer and an intermediate 21-gene recurrence score. The evaluation procedure comprised registry completeness, measurement errors, trend analysis and calculation of risk. Two patients, 23- and 30-year-old males, presented with intermittent symptoms of globe displacement, diplopia or discomfort months after repair of an orbital floor fracture with a synthetic orbital floor implant. Successful treatment of POEMS syndrome with bortezomib and dexamethasone, combined with radiotherapy, and followed by autologous stem cell transplantation.

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Paroxysmal nonkinesigenic dyskinesia (PNKD) consists of episodes of chorea, athetosis, or dystonia which are not triggered by movement, with complete remission between episodes. The clinical trial involved a control and experimental group and pre-post intervention measurements, using the Goldberg Scale. Remote limb ischemic preconditioning is readily instituted and used in several ongoing cardiac studies for ischemic myocardial protection.

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This report underscores the importance of obtaining longer chromosome preparations above the current recommended 400 BPHS for prenatal specimens. Unsuspected pheochromocytoma: risk of blood-pressure alterations during percutaneous adrenal biopsy.

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Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. When 5-azacytidine is applied to embryos of triticale and wheat x rye F1 hybrids nine, or more, days after fertilization, rye rRNA gene expression is stably reactivated in the resulting seedling. Thrombocyte morphology scores (TMS) were calculated for each blood sample. Hyperphosphorylated tau is implicated in acquired epilepsy and neuropsychiatric comorbidities.

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However, in marked contrast to IL-12-deficient animals, a significant increase in IFN-gamma-producing cells likely explains the reduced Th2 response in IL-10/IL-12-deficient mice. Sellar tumors can be removed via the LSO approach with relatively low morbidity and mortality.

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Muscle plasticity: comparison of a 30-Hz burst with 10-Hz continuous stimulation. Effect of antioxidants and B-group vitamins on risk of infections in patients with type 2 diabetes mellitus. Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines. When referenced to body surface area, the differences between Caucasians and Chinese were insignificant. It is shown that electromagnetic vortices can act as beam guides for charged particles.

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Current concepts in ocular melanoma: first of a series of CJO special issues. This effect was most pronounced in colon descendens and sigmoideum with an odds ratio (OR) of 0.49 whereas no reduced risk was found for right-sided colon cancer. Further, to assess the incidence of AIDS and the main characteristics of women affected by AIDS: with particular attention to those aged 25-34 years, and to identify differences in these characteristics compared with men infected with AIDS.

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Effect of moderate hypothermia on intracranial pressure and brain tissue oxygen tension in head injury Although renal hypertrophy occurs rapidly after uninephrectomy, restoring the majority of renal excretory function, it remains unknown whether similar compensatory mechanisms maintain 1,25-dihydroxyvitamin D production (and calcium homeostasis). Optimal insulin therapy on CAPD: intraperitoneal versus subcutaneous treatment. First MR was undertaken during the acute relapse, afterwards patients were given cortisone therapy for four to six weeks.

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