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Sophivir (Acyclovir)

Sophivir is approved by the Food and Drug Administration as a prescription drug that is commonly used as a topical, injectable, and oral treatment for genital herpes and cold sores. Herpes refers to a group of viruses that cause a variety of herpes infections including genital herpes, shingles, chicken pox (also chickenpox), cold sores, and encephalitis (inflammation of the brain). Herpes viral infections are very common. Genital herpes refers to a sexually transmitted disease (STD) that any sexually active person can contract and transmit. Shingles and chicken pox are common skin conditions.Shingles and chicken pox are skin infections which are both caused by the herpes virus. They are not caused by the same virus that causes cold sores or genital herpes. Many people who suffer from shingles or chicken pox (chickenpox) infection will experience symptoms such as a rash, often with pain, which is treatable with this drug. Genital herpes is an STD caused by two types of viruses: herpes simplex type 1 and herpes simplex type 2. Most people with genital herpes do not know they have it. Still, symptoms often appear days to weeks after exposure.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Viroclear, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

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Sophivir comes as a tablet, a capsule, and a suspension (liquid) to take by mouth. It also comes as a delayed-release buccal tablet to apply to the upper gum of the mouth. The tablets, capsules, and suspension are usually taken with or without food two to five times a day for 5 to 10 days, starting as soon as possible after your symptoms begin. When Sophivir is used to prevent outbreaks of genital herpes, it is usually taken two to five times a day for up to 12 months. The delayed-release buccal tablet is usually applied with a dry finger as a one-time dose within 1 hour after itching, redness, burning or tingling cold sore symptoms begin but before the cold sore appears. Take or use Sophivir at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take or use Sophivir exactly as directed. Do not take or use more or less of it or take it more often or for a longer time than prescribed by your doctor.

Do not chew, crush, suck, or swallow the delayed-release buccal tablets. Drink plenty of liquids, if you have a dry mouth while using the delayed-release buccal tablets.

To use buccal Sophivir, follow these steps:

  1. Find the area on the upper gum above your left and right incisor teeth (the teeth just to the left and right of your two front teeth).
  2. With dry hands, remove one delayed-release tablet from the container.
  3. Gently apply the tablet to the upper gum area as high as it will go on your gum above one of your incisor teeth on the side of your mouth with the cold sore. Do not apply it to the inside of the lip or cheek.
  4. Hold the tablet in place for 30 seconds.
  5. If the tablet does not stick to your gum or if it sticks to your cheek or the inside of your lip, reposition it to stick to your gum. Leave the tablet in place until it dissolves.
  6. Do not interfere with the placement of the tablet. Check to see if the tablet is still in place after eating, drinking, or rinsing your mouth.

If the delayed-release buccal tablet comes off within the first 6 hours of application, reapply the same tablet. If it still will not stick, then apply a new tablet. If you accidentally swallow the tablet within the first 6 hours of application, drink a glass of water and place a new tablet on your gum. If the tablet falls off or is swallowed 6 or more hours after application, do not apply a new tablet until your next regular time.

Avoid the following while you are using Sophivir buccal delayed-release tablet:

  • Do not chew gum, touch, or press the buccal tablet after it has been applied.
  • Do not wear upper dentures.
  • Do not brush your teeth until it dissolves. If your teeth need to be cleaned while the tablet is in place, rinse the mouth gently.

Shake the suspension well before each use to mix the medication evenly.

Your symptoms should improve during your treatment with Sophivir. Call your doctor if your symptoms do not improve or if they get worse.

Take or use Sophivir until you finish the prescription, even if you feel better. If you stop taking Sophivir too soon or skip doses, your infection may not be completely treated or may become more difficult to treat. The delayed-release buccal tablet is applied as a one-time dose.

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Asm is a novel, powerful regulator of mast cell function and thus a potential target in the treatment of allergic reactions. Thoracoscopic color and fluorescence imaging system for sentinel lymph node mapping in porcine lung using indocyanine green-neomannosyl human serum albumin: intraoperative image-guided sentinel nodes navigation. The same factors that explain differences between happy and unhappy people in social indicators research also appeared to be determinants of different trajectories of adaptation in the wake of a life-threatening illness. However, the tubular and reticular abnormalities coincided with delta antigen expression in liver biopsies detected by direct immunoperoxidase staining and abnormal alanine aminotransferase levels in the serum, which suggests a possible causal relationship.

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It synthesizes apolipoproteins (e.g., apo A I, apo C II, apo E), lecithin cholesterol acyltransferase, hepatic lipase and is responsible for the chylomicron remnant removal. Aberrant functionality of the ubiquitin proteasome system (UPS) has been implicated in the pathology of various neurological disorders.

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